Colchicine
- OralColchicineColgout
Mechanism of Action
- Inhibits microtubule polymerisation, resulting in reduced mitosis. Also inhibits the release of a crystal-derived factor from neutrophils.
Clinical Use
- Indications
- Prophylaxis and treatment of gout flares
- Pericarditis (off-label)
- Adverse Effects
- Diarrhoea / nausea / vomiting
- Fatigue