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Codeine

  •  
    Oral
    Codeine
    Weakly agonises all opioid receptors
    Up to 10% of the population lack the enzyme required to convert codeine (weak) to morphine (potent) – in these cohorts codeine has nearly no effect
    • Mechanism of Action
    • Acts on opioid receptors (δ, κ and µ) and nociceptin orphanin FQ (NOF) receptors on neuronal cell membranes within the thalamus, diencephalon, midbrain and medulla, resulting in reduced neurotransmitter release.

Clinical Use

    • Indications
    • Acute and chronic pain
    • Adverse Effects
    • Nausea / vomiting
    • Constipation
    • Sedation
    • Respiratory depression
    • Diaphoresis
    • Delirium
    • Hypersensitivity – bronchospasm, urticaria
    • Bradycardia
    • Tolerance
    • Dependence
    • Hypogonadism

Associated Adverse Effects
BETA

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