- OralClozapineClopine, Clozaril5-HT2A and D4 receptor blocker, with weak D2 receptor antagonism
Used for treatment-resistant schizophrenia
Causes myocarditis / myopathy, agranulocytosis
- Mechanism of Action
- Seems to cause transient antagonism of D2 receptors, as well as serotonin 5-HT2A antagonism.
- Less extrapyramidal adverse effects and less hyperprolactinaemia than first generation antipsychotics.
- Adverse Effects