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Drug Guide
 
 

Clozapine

 
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    Oral
    Clozapine
    Clopine, Clozaril 
     
    5-HT2A and D4 receptor blocker, with weak D2 receptor antagonism
    Used for treatment-resistant schizophrenia

    Causes myocarditis / myopathy, agranulocytosis
    • Mechanism of Action
    • Seems to cause transient antagonism of D2 receptors, as well as serotonin 5-HT2A antagonism.
    • Pharmacology
    • Less extrapyramidal adverse effects and less hyperprolactinaemia than first generation antipsychotics.

Clinical Use

    • Indications
    • Adverse Effects
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