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Drug Guide

Clopidogrel + Aspirin

    Clopidogrel + Aspirin
  • Mechanism of Action

  • Irreversibly inhibit the binding of adenosine diphosphate (ADP) to platelet P2Y₁₂ receptors, resulting in reduced platelet activation and aggregation.
  • Pharmacology

  • Clopidogrel is a pro-drug that requires enzymatic activation.

Clinical Use

  • Indications
  • Acute coronary syndrome (in conjunction with aspirin)
  • Prevention of in-stent thrombosis following percutaneous coronary intervention
  • Prevention of vascular ischaemia following stroke, MI or peripheral vascular disease (clopidogrel)
  • Contraindications
  • Active bleeding
  • Intracranial haemorrhage
  • Adverse Effects
  • Haemorrhage
  • Gastritis / peptic ulceration
  • Nephrotoxicity
  • Delirium
  • Headache
  • Elevated LFTs
  • Neutropaenia
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