Clopidogrel + Aspirin

    Clopidogrel + Aspirin
    • Mechanism of Action
    • Irreversibly inhibit the binding of adenosine diphosphate (ADP) to platelet P2Y₁₂ receptors, resulting in reduced platelet activation and aggregation.
    • Pharmacology
    • Clopidogrel is a pro-drug that requires enzymatic activation.

Clinical Use

    • Indications
    • Acute coronary syndrome (in conjunction with aspirin)
    • Prevention of in-stent thrombosis following percutaneous coronary intervention
    • Prevention of vascular ischaemia following stroke, MI or peripheral vascular disease (clopidogrel)
    • Contraindications
    • Active bleeding
    • Intracranial haemorrhage
    • Adverse Effects
    • Haemorrhage
    • Gastritis / peptic ulceration
    • Nephrotoxicity
    • Delirium
    • Headache
    • Elevated LFTs
    • Neutropaenia
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