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Drug Guide
 
 

Clopidogrel

 
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    Oral
    Clopidogrel
    Plavix 
     
    A prodrug that requires enzymatic activation
  • Mechanism of Action

  • Irreversibly inhibits the binding of adenosine diphosphate (ADP) to platelet P2Y₁₂ receptors, resulting in reduced platelet activation and aggregation.
  • Pharmacology

  • A pro-drug that requires enzymatic activation.

Clinical Use

  • Indications
  • Acute coronary syndrome (in conjunction with aspirin)
  • Prevention of in-stent thrombosis following percutaneous coronary intervention
  • Prevention of vascular ischaemia following stroke, MI or peripheral vascular disease
  • Contraindications
  • Active bleeding
  • Intracranial haemorrhage
  • Adverse Effects

  • Haemorrhage.
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