Clonazepam
- Oral / IVClonazepamPaxam, Rivotril[Peak] 2-3 hours
Half-life 18-50 hours
Mechanism of Action
- Positively modulates GABAA receptors (BZ1 and BZ2), augmenting the inhibitory effects of the GABA neurotransmitter.
Clinical Use
- Indications
- Acute anxiety
- Tranquilization - in the acute psychiatric setting
- Status epilepticus
- Adverse Effects
- Drowsiness
- Hypersalivation
- Muscle weakness
- Vertigo