Clindamycin

• Mechanism of Action
• Inhibits protein synthesis by binding to the 50s ribosomal subunit, resulting in inaccurate mRNA translation.
• • Microbiology
  • Effective against staphylococci, streptococci, pneumococci and most anaerobes.

Clinical Use

• • Indications
  • Severe gram positive infections:
  • Upper / lower respiratory tract infections
  • Skin infections
  • Osteomyelitis / septic arthritis
  • Septicaemia
• • Adverse Effects
  • Hypersensitivity reactions
  • Nausea / vomiting / diarrhoea
  • Elevated LFTs