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Drug Guide


  • Mechanism of Action

  • An alkylating agent that binds to DNA, causing intrastrand and interstrand crosslinks that change DNA conformation and affect replication.

Clinical Use

  • Indications

  • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
  • Adverse Effects
  • Bone marrow suppression - leucopaenia, thrombocytopaenia, anaemia
  • Renal dysfunction
  • Nausea / vomiting
  • Elevated LFTs
  • Ototoxicity - tinnitus, hearing loss
  • Transient loss of vision
  • Peripheral neuropathy
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