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Cisplatin

  •  
    IV
    Cisplatin
    Platinol 
    • Mechanism of Action
    • An alkylating agent that binds to DNA, causing intrastrand and interstrand crosslinks that change DNA conformation and affect replication.

Clinical Use

    • Indication
    • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
    • Adverse Effects
    • Bone marrow suppression ­– leucopaenia, thrombocytopaenia, anaemia
    • Renal dysfunction
    • Nausea / vomiting
    • Elevated LFTs
    • Ototoxicity – tinnitus, hearing loss
    • Transient loss of vision
    • Peripheral neuropathy

Associated Adverse Effects
BETA

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