Chlorpromazine | Drug Guide - MedSchool
Sign up to start your free trial of MedSchool Premium!Get Started
 
Drug Guide
 
 
#
A
B
C
D
E
F
G
H
I
K
L
M
N
O
P
Q
R
S
T
U
V
W
Z
 

Chlorpromazine

Bookmark
  •  
    Oral / IV
    Chlorpromazine
    Largactil 
    • Mechanism of Action
    • Inhibits dopamine D2 receptors, resulting in reduced dopaminergic transmission within the four dopaminergic pathways. Also inhibits serotonin (5-HT), muscarinic and α1-adrenergic receptors.
    • Pharmacology
    • More extrapyramidal side effects than atypical antipsychotics.

Clinical Use

    • Indications
    • Psychosis – schizophrenia, and related disorders
    • Acute mania
    • Tranquilization – in the acute psychiatric setting
    • Status migrainosus
    • Adverse Effects
    • Anticholinergic – dry mouth, blurred vision, constipation, urinary retention, delirium
    • Extrapyramidal – dystonia, akathisia, parkinsonism, tardive dyskinesia
    • Hyperprolactinaemia – gynaecomastia, galactorrhoea, infertility, sexual dysfunction
    • Drowsiness
    • Postural hypotension
    • Prolonged QTc
    • Dyslipidaemia
    • Weight gain
 
Feedback