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Drug Guide



  • Mechanism of Action

  • Believed to inhibit haem polymerisation, resulting in a buildup of toxic haem molecules into non-toxic haemozoin within the food vacuole of plasmodia.
  • Microbiology

  • Widespread resistance, therefore rarely used in many countries.

Clinical Use

  • Indications
  • Prevention of malaria
  • Acute Plasmodium malariae or falciparum infection
  • Adverse Effects
  • Nausea / vomiting
  • Elevated LFTs
  • Headache
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