Chloroquine
- OralChloroquine
Mechanism of Action
- Believed to inhibit haem polymerisation, resulting in a buildup of toxic haem molecules into non-toxic haemozoin within the food vacuole of plasmodia.
Microbiology
- Widespread resistance, therefore rarely used in many countries.
Clinical Use
- Indications
- Prevention of malaria
- Acute Plasmodium malariae or falciparum infection
- Adverse Effects
- Nausea / vomiting
- Elevated LFTs
- Headache