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Cetuximab

  •  
    IV
    Cetuximab
    Erbitux 
    • Mechanism of Action
    • A monoclonal antibody directed against epidermal growth factor receptor (EGFR / HER1), which is involved in cell signalling and is overexpressed in certain cancers. Inhibition of EGFR signalling pathways results in cell cycle arrest.

Clinical Use

    • Indications
    • Metastatic colorectal cancer that is EGFR positive, RAS wild type
    • Locally advanced / metastatic squamous cell cancer of the head & neck
    • Contraindications
    • May not be used in the presence of RAS or BRAF mutations (must be wild type).
    • Adverse Effects
    • Acneiform rash
    • Nausea / vomiting / diarrhoea / constipation
    • Abdominal pain
    • Headache
    • Fatigue
    • Anorexia
    • Hypomagnesaemia
    • Elevated LFTs
    • Anaemia

Potential Indications
BETA

Colorectal Cancer

Associated Adverse Effects
BETA

Electrolyte Abnormalities
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