Cetuximab

• Mechanism of Action
• A monoclonal antibody directed against epidermal growth factor receptor (EGFR / HER1), which is involved in cell signalling and is overexpressed in certain cancers. Inhibition of EGFR signalling pathways results in cell cycle arrest.

Clinical Use

• • Indications
• • Contraindications
  • May not be used in the presence of RAS or BRAF mutations (must be wild type).
• • Adverse Effects