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Drug Guide
 
 

Cetuximab

 
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  •  
    IV
    Cetuximab
    Erbitux 

  • Mechanism of Action

  • A monoclonal antibody directed against epidermal growth factor receptor (EGFR / HER1), which is involved in cell signalling and is overexpressed in certain cancers. Inhibition of EGFR signalling pathways results in cell cycle arrest.

Clinical Use

  • Indications
  • Metastatic colorectal cancer that is EGFR positive, RAS wild type
  • Locally advanced / metastatic squamous cell cancer of the head & neck

  • Contraindications

  • May not be used in the presence of RAS or BRAF mutations (must be wild type).
  • Adverse Effects
  • Acneiform rash
  • Nausea / vomiting / diarrhoea / constipation
  • Abdominal pain
  • Headache
  • Fatigue
  • Anorexia
  • Hypomagnesaemia
  • Elevated LFTs
  • Anaemia
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