Drug Guide
 

Ceritinib

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    Oral
    Ceritinib
    Zykadia 
     
    Better CNS penetration than crizotinib
    • Mechanism of Action
    • Anaplastic lymphoma kinase (ALK) is a novel receptor tyrosine kinase associated with ~60% of anaplastic large-cell lymphoma and ~5% of non-small cell lung cancer. Inhibition of these receptors interrupts downstream signalling pathways and suppresses cellular proliferation.

Clinical Use

    • Indication
    • ALK-positive locally advanced or metastatic non small cell lung cancer (NSCLC).
    • Adverse Effects
    • Visual phenomena
    • Nausea / vomiting / diarrhoea
    • Neutropaenia
    • Pneumonitis
    • LFT derangement
    • Bradycardia
    • Oedema
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