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Drug Guide
 
 

Cephazolin

 
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 View Topic Outline
  •  
    IV
    Cephazolin
    Used for severe infections and for surgical prophylaxis
  • Mechanism of Action
  • A beta lactam antibiotic that inhibits bacterial cell wall synthesis.
  • Broken down by beta lactamase enzymes produced by some bacteria.

  • Microbiology

  • Most effective against gram positive cocci (streptococci and staphylococci), as well as Proteus spp., E coli and Klebsiella spp.

Clinical Use

  • Indications
  • Upper / lower respiratory tract infections
  • Skin infections
  • Urinary tract infections
  • Adverse Effects
  • Very few compared to penicillins.
  • Thrombophlebitis
  • Hypersensitivity reactions
  • Nausea / vomiting / diarrhoea
  • Pseudomembranous colitis (C difficile)
  • Thrombocytopaenia / leukopaenia
  • Nephrotoxicity
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