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Drug Guide


  • Mechanism of Action

  • Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
  • Pharmacology

  • Selectively binds to COX2, resulting in reduced gastritis / peptic ulceration compared to non-selective NSAIDs.

Clinical Use

  • Indications
  • Pain - including migraine and musculoskeletal injury
  • Fever
  • Inflammation - especially associated with arthritides
  • Prophylaxis (aspirin) - of acute coronary or cerebrovascular events in patients with known cardiovascular or cerebrovascular disease
  • Adverse Effects
  • Gastritis / peptic ulceration
  • Nephrotoxicity
  • Hypertension / fluid retention / congestive cardiac failure / MI
  • Hypersensitivity reactions
  • Delirium
  • Headache
  • Elevated LFTs
  • Neutropaenia
  • Thrombosis
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