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Ceftriaxone

  •  
    IV
    Ceftriaxone

    • Mechanism of Action
    • A beta lactam antibiotic that inhibits bacterial cell wall synthesis.
    • Pharmacology
    • Crosses the blood brain barrier - useful against meningitis.
    • Microbiology
    • More active against gram negative bacteria (Haemophilus, Enterobacteriaciae), less active against gram positive bacteria and inactive against MRSA.

Clinical Use

    • Indications
    • Upper / lower respiratory tract infections
    • Skin infections
    • Urinary tract infections
    • Adverse Effects
    • Very few compared to penicillins.
    • Thrombophlebitis
    • Hypersensitivity reactions
    • Nausea / vomiting / diarrhoea
    • Pseudomembranous colitis (C difficile)
    • Thrombocytopaenia / leukopaenia
    • Nephrotoxicity

Associated Adverse Effects
BETA

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