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Drug Guide


    β1, β2 and α1 antagonist effects
  • Mechanism of Action
  • Competitively inhibits the action of adrenaline and noradrenaline on β1 and β2 receptors, resulting in reduced contractility, reduced heart rate and vasoconstriction.
  • Also inhibits α1 receptors, resulting in vasodilatation.

Clinical Use

  • Indications
  • Hypertension - second line therapy, indicated for patients with heart failure
  • Heart failure
  • Contraindications
  • Asthma
  • Decompensated heart failure
  • AV block
  • Adverse Effects
  • Fatigue / headache
  • Bradycardia
  • Postural hypotension
  • Vivid dreams
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