- Mechanism of Action
- An alkylating agent that binds to DNA, causing intrastrand and interstrand crosslinks that change DNA conformation and affect replication.
Clinical Use
- Indication
- Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
- Adverse Effects
- Bone marrow suppression – leucopaenia, thrombocytopaenia, anaemia
- Renal dysfunction
- Nausea / vomiting
- Elevated LFTs
- Ototoxicity – tinnitus, hearing loss
- Transient loss of vision
- Peripheral neuropathy
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