Carboplatin

• Mechanism of Action
• An alkylating agent that binds to DNA, causing intrastrand and interstrand crosslinks that change DNA conformation and affect replication.

Clinical Use

• • Indication
  • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
• • Adverse Effects
  • Bone marrow suppression ­– leucopaenia, thrombocytopaenia, anaemia
  • Renal dysfunction
  • Nausea / vomiting
  • Elevated LFTs
  • Ototoxicity – tinnitus, hearing loss
  • Transient loss of vision
  • Peripheral neuropathy