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Carbimazole

  •  
    Oral
    Carbimazole
    Neo-Mercazole
    • Mechanism of Action
    • Prevents utilization of iodine by the thyroid by inhibiting thyroperoxidase-catalysed iodination of tyrosine residues within the thyroid
      Suspected to have immunosuppressive effects by affecting signaling pathways between thyroid cells and T cells.

Clinical Use

    • Indication
    • Hyperthyroidism, either as a sole agent or prior to surgery / radioiodine.
    • Adverse Effects
    • Rash
    • Foetal abnormalities
    • Neutropaenia / thrombocytopaenia
    • Cholestatic LFT derangement

Potential Indications
BETA

Thyrotoxicosis
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