Oral
Carbamazepine
Tegretol
- Mechanism of Action
- Inhibits voltage-gated sodium channels, preventing the propagation of action potentials and thus suppressing seizure activity.
Clinical Use
- Indications
- Partial (focal) seizures
- Acute mania
- Trigeminal neuralgia
- Adverse Effects
- CNS disturbances – drowsiness, ataxia, headache, diplopia
- Nausea / vomiting
- Rash
- Anticonvulsant hypersensitivity syndrome (prolonged admin) – fever, rash, lymphadenopathy, hepatitis, myositis
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