Carbamazepine
- OralCarbamazepineTegretol
Mechanism of Action
- Inhibits voltage-gated sodium channels, preventing the propagation of action potentials and thus suppressing seizure activity.
Clinical Use
- Indications
- Partial (focal) seizures
- Acute mania
- Trigeminal neuralgia
- Adverse Effects
- CNS disturbances - drowsiness, ataxia, headache, diplopia
- Nausea / vomiting
- Rash
- Anticonvulsant hypersensitivity syndrome (prolonged admin) - fever, rash, lymphadenopathy, hepatitis, myositis