Capecitabine
- OralCapecitabineXelodaConverted to 5-fluorouracil once absorbed orally
Mechanism of Action
- Inhibits thymidylate synthase, resulting in reduced production of dTMP and reduced DNA synthesis.
Clinical Use
Indications
- Certain solid organ malignancies, as guided by cancer specialists and local guidelines.
- Adverse Effects
- Severe diarrhoea
- Nausea / vomiting
- Alopecia
- Leucopaenia