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Bupivacaine

  •  
    Local / Regional / Epidural
    Bupivacaine
    Marcain 
    • Mechanism of Action
    • Binds to and inhibits neuronal voltage-gated sodium channels, suppressing neuronal depolarization and preventing axonal propagation of action potentials.

Clinical Use

    • Indications
    • Procedural anaesthesia – local anaesthesia, nerve block or epidural block
    • Analgesia – local anaesthesia or epidural block
    • Adverse Effects
    • Hypersensitivity reactions – rash, oedema, anaphylaxis
    • Inadvertent IV administration – agitation, drowsiness, bradycardia, hypotension, ventricular arrhythmia, hyperkalaemia, hypoxia

Associated Adverse Effects
BETA

Electrolyte Abnormalities
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