Local / Regional / Epidural
Bupivacaine
Marcain
- Mechanism of Action
- Binds to and inhibits neuronal voltage-gated sodium channels, suppressing neuronal depolarization and preventing axonal propagation of action potentials.
Clinical Use
- Indications
- Procedural anaesthesia – local anaesthesia, nerve block or epidural block
- Analgesia – local anaesthesia or epidural block
- Adverse Effects
- Hypersensitivity reactions – rash, oedema, anaphylaxis
- Inadvertent IV administration – agitation, drowsiness, bradycardia, hypotension, ventricular arrhythmia, hyperkalaemia, hypoxia
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