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Drug Guide
 
 

Bupivacaine

 
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 View Topic Outline
  •  
    Local / Regional / Epidural
    Bupivacaine
    Marcain 

  • Mechanism of Action

  • Binds to and inhibits neuronal voltage-gated sodium channels, suppressing neuronal depolarization and preventing axonal propagation of action potentials.

Clinical Use

  • Indications
  • Procedural anaesthesia – local anaesthesia, nerve block or epidural block
  • Analgesia – local anaesthesia or epidural block
  • Adverse Effects
  • Hypersensitivity reactions – rash, oedema, anaphylaxis
  • Inadvertent IV administration – agitation, drowsiness, bradycardia, hypotension, ventricular arrhythmia, hyperkalaemia, hypoxia
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