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Bumetanide

  •  
    Oral
    Bumetanide

    • Mechanism of Action
    • Inhibits the sodium-potassium-chloride cotransporters in the thick ascending limb of the loop of Henle, normally responsible for 25% of tubular sodium reabsorption. Inhibition results in increased excretion of sodium and, with it, water.

Clinical Use

    • Indications
    • Peripheral oedema – due to congestive cardiac failure / renal failure / nephrotic syndrome / cirrhosis
    • Acute pulmonary oedema
    • Symptomatic ascites (second line treatment)
    • Adverse Effects
    • Hypokalaemia
    • Hyponatraemia
    • Dehydration / hypovolaemia
    • Hyperuricaemia
    • Muscle cramps
    • Headache
    • Hepatic encephalopathy in patients with liver disease

Potential Indications
BETA

Left Ventricular Failure
Right Ventricular Failure
Heart Failure with Reduced Ejection Fraction
Cirrhosis
Nephrotic Syndrome
Acute Pulmonary Oedema

Associated Adverse Effects
BETA

Hepatic Encephalopathy
Electrolyte Abnormalities
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