Cytotoxicity is cell cycle-specific to G2 phase
- Mechanism of Action
- Binds to DNA, resulting in prevention of RNA transcription and protein synthesis.
- Bone marrow-sparing, therefore often used when other antineoplastics are contraindicated.
- Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
- Adverse Effects
- Nausea / vomiting / diarrhoea / anorexia
- Soft tissue damage (if extravasation)
- Lung function.
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