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Drug Guide


    Cytotoxicity is cell cycle-specific to G2 phase
  • Mechanism of Action

  • Binds to DNA, resulting in prevention of RNA transcription and protein synthesis.
  • Pharmacology

  • Bone marrow-sparing, therefore often used when other antineoplastics are contraindicated.

Clinical Use

  • Indications

  • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
  • Adverse Effects
  • Nausea / vomiting / diarrhoea / anorexia
  • Pneumonitis
  • Alopecia
  • Soft tissue damage (if extravasation)
  • Monitoring

  • Lung function.
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