Bisoprolol
- OralBisoprololBicorUsed to treat stable heart failure only
Mechanism of Action
- Competitively inhibit the action of adrenaline and noradrenaline on β1 receptors (the predominant β receptors in the heart), resulting in suppression of the sympathetic nervous system with negative inotropy, chronotropy, dromotropy and lusiotropy.
Clinical Use
Indications
- Stable heart failure
- Contraindications
- Asthma
- Decompensated heart failure
- AV block
- Adverse Effects
- Fatigue / headache
- Bradycardia
- Postural hypotension
- Nausea / vomiting / diarrhoea