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Drug Guide
 
 

Bevacizumab

 
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    IV
    Bevacizumab
    Avastin 
  • Mechanism of Action

  • A humanised monoclonal antibody directed against vascular endothelial growth factor (VEGF), whose expression is up-regulated during angiogenesis in certain cancers. Binding to VEGF reduces tumour bloodflow by promoting breakdown of tumour vasculature and inhibiting new blood vessel growth.

Clinical Use

  • Indications
  • Metastatic colorectal cancer
  • Locally recurrent or metastatic breast cancer
  • Advanced, metastatic or recurrent non-squamous non-small cell lung cancer (NSCLC)
  • Advanced or metastatic renal cancer
  • Metastatic or unresectable melanoma
  • Epithelial ovarian, fallopian tube or primary peritoneal cancer
  • Recurrent or metastatic cervical cancer
  • Grade IV glioma
  • Adverse Effects
  • Bone marrow suppression – leucopaenia, anaemia, thrombocytopaenia
  • Peripheral neuropathy
  • Arterial / venous thromboembolism
  • Hypertension
  • Proteinuria
  • Nausea / vomiting / diarrhoea
  • Fatigue
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