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Drug Guide
 
 

Azathioprine

 
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 View Topic Outline
  •  
    Oral / IV
    Azathioprine
    Imuran 

  • Mechanism of Action

  • A prodrug that is converted to a purine analogue which inhibits purine synthesis, disrupting DNA synthesis and reducing T cell activation.

Clinical Use

  • Indications
  • Inflammatory disorders - rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, vasculitis
  • Prevention of rejection in renal transplantation
  • Adverse Effects
  • Bone marrow suppression - anaemia / leukopaenia / thrombocytopaenia
  • Gastrointestinal - nausea / vomiting / diarrhea
  • Hepatotoxicity - elevated LFTs
  • Skin - rash

  • Monitoring

  • Monthly full blood count, renal function and LFTs.
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