×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Drug Guide
 
 

Avelumab

 
Bookmark
  •  
    IV infusion
    Avelumab
    Bavencio 
    • Mechanism of Action
    • A monoclonal antibody directed against PD-L1, an inhibitory molecule expressed on certain tumour cells.
      PD-L1 and PD-L2 are ligands that bind to PD-1 receptors on activated lymphocytes and inhibit T cell receptor signalling, downregulating immune responses and promoting tolerance.
      Binding of anti-PD-L1 monoclonal antibodies leaves the ligand unable to bind to PD-1, and therefore stimulates an ongoing immune response.
      PD-L2 is not inhibited, allowing PD-1 / PD-L2 mediated inhibitory signals to continue.

Clinical Use

    • Indication
    • Metastatic Merkel cell carcinoma
    • Adverse Effects
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now