Atropine

• Mechanism of Action
• Inhibits the action of acetylcholine on muscarinic receptors, resulting in reduced vagal (parasympathetic) stimulation of the heart.
  
  Increases heart rate (positive chronotropy) and electrical conduction (positive dromotropy)

Clinical Use

• • Indications
  • Acetylcholinesterase inhibitor poisoning – organophosphates, chemical warfare, donepezil, rivastigmine, neostigmine
  • Acute bradyarrhythmia – organic, beta blocker / calcium channel blocker / digoxin overdose
  • Reduction in salivary and bronchial secretions preoperatively
• • Contraindications
  • Severe ulcerative colitis
  • Gastrointestinal obstruction
  • Obstructive uropathy
  • Glaucoma
• • Adverse Effects
  • Tachycardia
  • Dry mouth / nose / eyes / skin
  • Constipation
  • Urinary retention
  • Dilated pupils