Atropine | Drug Guide - MedSchool
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Atropine

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    IV / IM / Subcut
    Atropine

    • Mechanism of Action
    • Inhibits the action of acetylcholine on muscarinic receptors, resulting in reduced vagal (parasympathetic) stimulation of the heart.

      Increases heart rate (positive chronotropy) and electrical conduction (positive dromotropy)

Clinical Use

    • Indications
    • Acetylcholinesterase inhibitor poisoning – organophosphates, chemical warfare, donepezil, rivastigmine, neostigmine
    • Acute bradyarrhythmia – organic, beta blocker / calcium channel blocker / digoxin overdose
    • Reduction in salivary and bronchial secretions preoperatively
    • Contraindications
    • Severe ulcerative colitis
    • Gastrointestinal obstruction
    • Obstructive uropathy
    • Glaucoma
    • Adverse Effects
    • Tachycardia
    • Dry mouth / nose / eyes / skin
    • Constipation
    • Urinary retention
    • Dilated pupils
 
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