Atropine
- IV / IM / SubcutAtropine
- Mechanism of Action
- Inhibits the action of acetylcholine on muscarinic receptors, resulting in reduced vagal (parasympathetic) stimulation of the heart.
- Increases heart rate (positive chronotropy) and electrical conduction (positive dromotropy)
Clinical Use
- Indications
- Acetylcholinesterase inhibitor poisoning – organophosphates, chemical warfare, donepezil, rivastigmine, neostigmine
- Acute bradyarrhythmia – organic, beta blocker / calcium channel blocker / digoxin overdose
- Reduction in salivary and bronchial secretions preoperatively
- Contraindications
- Severe ulcerative colitis
- Gastrointestinal obstruction
- Obstructive uropathy
- Glaucoma
- Adverse Effects
- Tachycardia
- Dry mouth / nose / eyes / skin
- Constipation
- Urinary retention
- Dilated pupils