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Atovaquone + Proguanil

 
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 View Topic Outline
  •  
    Oral
    Atovaquone + Proguanil
    Malarone 
  • Mechanism of Action
  • Atovaquone - inhibits nucleic acid and ATP synthesis through disruption of the protozoal electron transport chain.
  • Proguanil - inhibits dihydrofolate reductase, resulting in reduced parasitic synthesis of deoxythymidilate.

  • Pharmacology

  • Must be taken the same time each day.

Clinical Use

  • Indications

  • Treatment and prevention of malaria (in combination with proguanil).

  • Adverse Effects

  • Nausea / vomiting / abdo pain.
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