Drug Guide
 

Atovaquone + Proguanil

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    Oral
    Atovaquone + Proguanil
    Malarone 
    • Mechanism of Action
    • Atovaquone - inhibits nucleic acid and ATP synthesis through disruption of the protozoal electron transport chain.
      Proguanil - inhibits dihydrofolate reductase, resulting in reduced parasitic synthesis of deoxythymidilate.
    • Pharmacology
    • Must be taken the same time each day.

Clinical Use

    • Indication
    • Treatment and prevention of malaria (in combination with proguanil).
    • Adverse Effects
    • Nausea / vomiting / abdo pain.
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