Atovaquone + Proguanil
- OralAtovaquone + ProguanilMalarone
- Mechanism of Action
- Atovaquone - inhibits nucleic acid and ATP synthesis through disruption of the protozoal electron transport chain.
Proguanil - inhibits dihydrofolate reductase, resulting in reduced parasitic synthesis of deoxythymidilate.
- Must be taken the same time each day.
- Treatment and prevention of malaria (in combination with proguanil).
- Adverse Effects
- Nausea / vomiting / abdo pain.