Aspirin + Dipyridamole

    Aspirin + Dipyridamole
    • Mechanism of Action
    • Aspirin inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
      Dypyridamole inhibits platelet cAMP-phosphodiesterase, preventing platelet aggregation. Also augments the platelet inhibitory effect of adenosine by preventing reuptake and degradation of adenosine by endothelial and red blood cells.

Clinical Use

    • Indications
    • Secondary prevention of stroke (in combination with aspirin)
    • Prevention of thromboembolism post prosthetic heart valve surgery (in combination with anticoagulants)
    • Adverse Effects
    • Nausea / vomiting / diarrhoea
    • Gastritis / peptic ulceration
    • Headache / dizziness
    • Nephrotoxicity
    • Vasodilation – flushing, hypotension
    • Elevated LFTs
    • Delirium
    • Neutropaenia
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