- Mechanism of Action
- Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
- Binds irreversibly to COX, unlike other NSAIDs. Though COX can resynthesize in minutes, platelets (which lack a nucleus) cannot create new COX and thus new platelets need to be produced, which can take up to a week. As a result aspirin is the only NSAID that significantly inhibits platelets and thus is also used for cardiovascular protection.
- Adverse Effects
- Gastritis / peptic ulceration
- Hypertension / fluid retention / congestive cardiac failure / MI
- Hypersensitivity reactions
- Elevated LFTs
Want more info like this?
- Your electronic clinical medicine handbook
- Guides to help pass your exams
- Tools every medical student needs
- Quick diagrams to have the answers, fast
- Quizzes to test your knowledge