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Drug Guide
 
 

Aspirin

 
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    Oral
    Aspirin
    Aspro, Astrix 
  • Mechanism of Action

  • Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
  • Pharmacology

  • Binds irreversibly to COX, unlike other NSAIDs. Though COX can resynthesize in minutes, platelets (which lack a nucleus) cannot create new COX and thus new platelets need to be produced, which can take up to a week. As a result aspirin is the only NSAID that significantly inhibits platelets and thus is also used for cardiovascular protection.

Clinical Use

  • Indications
  • Prophylaxis – of acute coronary or cerebrovascular events in patients with known cardiovascular or cerebrovascular disease
    Pain – including migraine and musculoskeletal injury
  • Fever
  • Inflammation – especially associated with arthritides
  • Adverse Effects
  • Gastritis / peptic ulceration
  • Nephrotoxicity
  • Hypertension / fluid retention / congestive cardiac failure / MI
  • Hypersensitivity reactions
  • Delirium
  • Headache
  • Elevated LFTs
  • Neutropaenia
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