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Aspirin

  •  
    Oral
    Aspirin
    Aspro, Astrix 
    • Mechanism of Action
    • Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
    • Pharmacology
    • Binds irreversibly to COX, unlike other NSAIDs. Though COX can resynthesize in minutes, platelets (which lack a nucleus) cannot create new COX and thus new platelets need to be produced, which can take up to a week. As a result aspirin is the only NSAID that significantly inhibits platelets and thus is also used for cardiovascular protection.

Clinical Use

    • Indications
    • Prophylaxis – of acute coronary or cerebrovascular events in patients with known cardiovascular or cerebrovascular disease
      Pain – including migraine and musculoskeletal injury
    • Fever
    • Inflammation – especially associated with arthritides
    • Adverse Effects
    • Gastritis / peptic ulceration
    • Nephrotoxicity
    • Hypertension / fluid retention / congestive cardiac failure / MI
    • Hypersensitivity reactions
    • Delirium
    • Headache
    • Elevated LFTs
    • Neutropaenia

    • Potential Indications
    BETA

    ST Elevation Myocardial Infarction
    Non-ST Elevation Myocardial Infarction
    Unstable Angina
    Stable Ischaemic Heart Disease
    Ischaemic Stroke
    Migraine

    Associated Adverse Effects
    BETA

    Secondary Hypertension
    Secondary Hypertension
    Gut
    Delirium
    Delirium
    Acute Kidney Injury
    Acute Kidney Injury
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