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Drug Guide
 
 

Aspirin

 
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    Oral
    Aspirin
    Aspro, Astrix 
    • Mechanism of Action
    • Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
    • Pharmacology
    • Binds irreversibly to COX, unlike other NSAIDs. Though COX can resynthesize in minutes, platelets (which lack a nucleus) cannot create new COX and thus new platelets need to be produced, which can take up to a week. As a result aspirin is the only NSAID that significantly inhibits platelets and thus is also used for cardiovascular protection.

Clinical Use

    • Indications
    • Adverse Effects
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