Drug Guide


    Aspro, Astrix 
    • Mechanism of Action
    • Inhibits cyclooxygenase, the enzyme responsible for production of thromboxanes, prostacyclin and prostaglandins from arachidonic acid.
    • Pharmacology
    • Binds irreversibly to COX, unlike other NSAIDs. Though COX can resynthesize in minutes, platelets (which lack a nucleus) cannot create new COX and thus new platelets need to be produced, which can take up to a week. As a result aspirin is the only NSAID that significantly inhibits platelets and thus is also used for cardiovascular protection.

Clinical Use

    • Indications
    • Prophylaxis – of acute coronary or cerebrovascular events in patients with known cardiovascular or cerebrovascular disease
      Pain – including migraine and musculoskeletal injury
    • Fever
    • Inflammation – especially associated with arthritides
    • Adverse Effects
    • Gastritis / peptic ulceration
    • Nephrotoxicity
    • Hypertension / fluid retention / congestive cardiac failure / MI
    • Hypersensitivity reactions
    • Delirium
    • Headache
    • Elevated LFTs
    • Neutropaenia
  • Want more info like this?
    • Your electronic clinical medicine handbook
    • Guides to help pass your exams
    • Tools every medical student needs
    • Quick diagrams to have the answers, fast
    • Quizzes to test your knowledge