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Apremilast

  •  
    Oral
    Apremilast
    Otezla 
    • Mechanism of Action
    • Inhibits phosphodiesterase 4 (PDE4), an enzyme that hydrolyses cAMP in many cell types. Increased cAMP results in reduced proinflammatory TNFα, IL-23 and IL-17, as well as increased anti-inflammatory IL-10.

Clinical Use

    • Indications
    • Psoriatic arthritis
    • Plaque psoriasis
    • Adverse Effects
    • Diarrhoea / nausea / vomiting
    • Infections (particularly upper respiratory tract infection)
    • Headache
    • Fatigue
    • Hypertension
    • Arthralgias / myalgias

Potential Indications
BETA

Psoriasis
Psoriatic Arthritis

Associated Adverse Effects
BETA

Secondary Hypertension
Secondary Hypertension
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