Mechanism of Action
- Directly inhibits factor Xa, resulting in reduced clot formation.
Pharmacology
- Andexanet alpha may be used to reverse apixaban in life-threatening situations only.
Clinical Use
- Indications
- Prevention of venous thromboembolism post hip / knee surgery
- Treatment of venous thromboembolism (DVT / PE)
- Non-valvular atrial fibrillation (prevention of stroke)
- Contraindications
- Active bleeding or risk of major bleeding
- Use of other anticoagulantsMechanical heart valve
- Severe renal impairment (eGFR
- Adverse Effects
- Haemorrhage
- Nausea / vomiting
Monitoring
- Anti-factor Xa assays may be used to assess for the therapeutic effect of apixaban, though there are no established target levels.
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