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Drug Guide


  • Mechanism of Action

  • Directly inhibits factor Xa, resulting in reduced clot formation.
  • Pharmacology

  • Andexanet alpha may be used to reverse apixaban in life-threatening situations only.

Clinical Use

  • Indications
  • Prevention of venous thromboembolism post hip / knee surgery
  • Treatment of venous thromboembolism (DVT / PE)
  • Non-valvular atrial fibrillation (prevention of stroke)
  • Contraindications
  • Active bleeding or risk of major bleeding
  • Use of other anticoagulantsMechanical heart valve
  • Severe renal impairment (eGFR
  • Adverse Effects
  • Haemorrhage
  • Nausea / vomiting
  • Monitoring

  • Anti-factor Xa assays may be used to assess for the therapeutic effect of apixaban, though there are no established target levels.
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