Login or Register to unlock everything MedSchool has to offer!
Full Drug List
 

#

A

B

C

D

E

F

G

H

I

K

N

O

P

Q

R

S

T

U

V

W

Z

 
 

Anakinra

  •  
    Subcut
    Anakinra
    Kineret 
    • Mechanism of Action
    • Interleukin-1 receptor antagonist (IL1-RA) is a naturally occurring protein that inhibits the binding of IL-1 to its receptor. Anakinra is human recombinant IL-1RA that competitively inhibits IL-1 binding, resulting in reduced acute phase response.

Clinical Use

    • Indications
    • Cryopyrin-associated periodic syndromes (CAPS) in adults and children 2 years or older
    • Systemic juvenile idiopathic arthritis refractory to non-biologic DMARDs
    • Rheumatoid arthritis refractory to one or more other DMARDs
    • Contraindications
    • Concurrent treatment with TNF-alpha inhibitors
    • Neutropaenia
    • Adverse Effects
    • Hypersensitivity reactions
    • Infections
    • Neutropaenia
    • Thrombocytopaenia
    • Headache
    • Nausea / vomiting / diarrhoea
    • LFT derangement
    • Hypercholesterolaemia

Potential Indications
BETA

Associated Adverse Effects
BETA

Feedback