Drug Guide
 

Anakinra

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    Subcut
    Anakinra
    Kineret 
    • Mechanism of Action
    • Interleukin-1 receptor antagonist (IL1-RA) is a naturally occurring protein that inhibits the binding of IL-1 to its receptor. Anakinra is human recombinant IL-1RA that competitively inhibits IL-1 binding, resulting in reduced acute phase response.

Clinical Use

    • Indications
    • Cryopyrin-associated periodic syndromes (CAPS) in adults and children 2 years or older
    • Systemic juvenile idiopathic arthritis refractory to non-biologic DMARDs
    • Rheumatoid arthritis refractory to one or more other DMARDs
    • Contraindications
    • Concurrent treatment with TNF-alpha inhibitors
    • Neutropaenia
    • Adverse Effects
    • Hypersensitivity reactions
    • Infections
    • Neutropaenia
    • Thrombocytopaenia
    • Headache
    • Nausea / vomiting / diarrhoea
    • LFT derangement
    • Hypercholesterolaemia
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