MedSchool: Ace Your OSCEsThe Medical Company
GET - On the App Store
Drug Guide


  • Mechanism of Action

  • Interleukin-1 receptor antagonist (IL1-RA) is a naturally occurring protein that inhibits the binding of IL-1 to its receptor. Anakinra is human recombinant IL-1RA that competitively inhibits IL-1 binding, resulting in reduced acute phase response.

Clinical Use

  • Indications
  • Cryopyrin-associated periodic syndromes (CAPS) in adults and children 2 years or older
  • Systemic juvenile idiopathic arthritis refractory to non-biologic DMARDs
  • Rheumatoid arthritis refractory to one or more other DMARDs
  • Contraindications
  • Concurrent treatment with TNF-alpha inhibitors
  • Neutropaenia
  • Adverse Effects
  • Hypersensitivity reactions
  • Infections
  • Neutropaenia
  • Thrombocytopaenia
  • Headache
  • Nausea / vomiting / diarrhoea
  • LFT derangement
  • Hypercholesterolaemia
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now

Snapshot: Initialising...