Drug Guide
 

Amphotericin B

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    IV
    Amphotericin B

    • Mechanism of Action
    • Binds to ergosterol on the cell membrane, resulting in the formation of pores, leakage of cytoplasmic components and cell death.
    • Microbiology
    • Effective against Candida, Cryptococcus and Aspergillus.

Clinical Use

    • Indication
    • Systemic candidiasis, cryptococcal meningitis, aspergillosis
    • Adverse Effects
    • Infusion reactions - fevers, rigors, arthralgias, hypotension, bronchospasm
    • Nephrotoxicity
    • Anaemia
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