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Amphotericin B

 
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  •  
    IV
    Amphotericin B

  • Mechanism of Action

  • Binds to ergosterol on the cell membrane, resulting in the formation of pores, leakage of cytoplasmic components and cell death.

  • Microbiology

  • Effective against Candida, Cryptococcus and Aspergillus.

Clinical Use

  • Indications

  • Systemic candidiasis, cryptococcal meningitis, aspergillosis
  • Adverse Effects
  • Infusion reactions - fevers, rigors, arthralgias, hypotension, bronchospasm
  • Nephrotoxicity
  • Anaemia
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