- Mechanism of Action
- Binds to ergosterol on the cell membrane, resulting in the formation of pores, leakage of cytoplasmic components and cell death.
- Microbiology
- Effective against Candida, Cryptococcus and Aspergillus.
Clinical Use
- Indication
- Systemic candidiasis, cryptococcal meningitis, aspergillosis
- Adverse Effects
- Infusion reactions - fevers, rigors, arthralgias, hypotension, bronchospasm
- Nephrotoxicity
- Anaemia
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