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Amoxycillin-Clavulanate

 
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  •  
    Oral
    Amoxycillin-Clavulanate
    Augmentin 

  • Mechanism of Action

  • Amoxycillin is a beta lactam antibiotic that inhibits bacterial cell wall synthesis. Clavulanate is a a beta lactamase inhibitor that has no intrinsic antimicrobial activity but prevents breakdown of beta lactam by beta lactamase enzyme.

Clinical Use

  • Indications
  • Community-acquired pneumonia
  • Peritonsillar abscess
  • Bacterial endocarditis
  • Rheumatic fever
  • Syphilis
  • Adverse Effects
  • Hypersensitivity - urticarial rash, oedema, anaphylaxis
  • GIT - nausea / vomiting / diarrhoea
  • Thrombocytopaenia / leukopaenia
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