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Amitriptyline

 
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  •  
    Oral
    Amitriptyline
    Endep 

  • Mechanism of Action

  • Blocks presynaptic reuptake of serotonin (5-HT) and noradrenaline (NA) through an unknown mechanism.

Clinical Use

  • Indications
  • Depression
  • Fibromyalgia
  • Migraine prophylaxis
  • Neuropathic pain
  • Post-traumatic stress disorder (PTSD)

  • Contraindications

  • Not for concurrent use with monoamine oxidase inhibitors (MAOi).
  • Adverse Effects
  • Nausea / vomiting / diarrhea
  • Adrenergic - postural hypotension
  • Histaminic - sedation, weight gain
  • Anticholinergic - dry mouth, blurred vision, constipation, urinary retention
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