Drug Guide
 

Amiodarone

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    IV / Oral
    Amiodarone
    Cordarone 
    • Mechanism of Action
    • Binds to and inhibits potassium channels responsible for repolarisation in phase 3 of the cardiomyocyte action potential, thus increasing the absolute refractory period (ARP).

Clinical Use

    • Indications
    • Cardioversion of atrial fibrillation
    • Acute management of ventricular tachycardia
    • Severe refractory tachyarrhythmias - Wolff-Parkinson-White / supraventricular tachycardia, atrial fibrillation / flutter
    • Adverse Effects
    • Elevated LFTs
    • Torsade de pointes
    • Bradycardia
    • Hypotension
    • Hypo / Hyperthyroidism
    • Extrapyramidal effects
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