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Drug Guide


    Second-line treatment when other aminoglycosides ineffective
  • Mechanism of Action

  • Inhibits protein synthesis by binding to the 30s ribosomal subunit, resulting in inaccurate mRNA translation.
  • Microbiology

  • Active against Pseudomonas and most Enterobacteriaciae.

Clinical Use

  • Indications
  • Gram negative septicaemia
  • Directed therapy for severe and susceptible respiratory infections, UTI, skin infections, osteomyelitis or peritonitis
  • Adverse Effects
  • Nephrotoxicity - reversible, higher risk with poor renal function
  • Ototoxicity -  irreversible vestibular and auditory dysfunction
  • Peripheral neuropathy
  • Hypersensitivity reactions
  • Monitoring
  • To ensure therapeutic levels and prevent toxic levels:
  • Clinically - monitor for ataxia and hearing loss
  • Bloods - monitor serum amikacin levels and creatinine / urea
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