Amikacin
- IVAmikacinSecond-line treatment when other aminoglycosides ineffective
Mechanism of Action
- Inhibits protein synthesis by binding to the 30s ribosomal subunit, resulting in inaccurate mRNA translation.
Microbiology
- Active against Pseudomonas and most Enterobacteriaciae.
Clinical Use
- Indications
- Gram negative septicaemia
- Directed therapy for severe and susceptible respiratory infections, UTI, skin infections, osteomyelitis or peritonitis
- Adverse Effects
- Nephrotoxicity - reversible, higher risk with poor renal function
- Ototoxicity - irreversible vestibular and auditory dysfunction
- Peripheral neuropathy
- Hypersensitivity reactions
- Monitoring
- To ensure therapeutic levels and prevent toxic levels:
- Clinically - monitor for ataxia and hearing loss
- Bloods - monitor serum amikacin levels and creatinine / urea