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Amikacin

  •  
    IV
    Amikacin
    Second-line treatment when other aminoglycosides ineffective
    • Mechanism of Action
    • Inhibits protein synthesis by binding to the 30s ribosomal subunit, resulting in inaccurate mRNA translation.
    • Microbiology
    • Active against Pseudomonas and most Enterobacteriaciae.

Clinical Use

    • Indications
    • Gram negative septicaemia
    • Directed therapy for severe and susceptible respiratory infections, UTI, skin infections, osteomyelitis or peritonitis
    • Adverse Effects
    • Nephrotoxicity – reversible, higher risk with poor renal function
    • Ototoxicity –  irreversible vestibular and auditory dysfunction
    • Peripheral neuropathy
    • Hypersensitivity reactions
    • Monitoring
    • To ensure therapeutic levels and prevent toxic levels:
    • Clinically – monitor for ataxia and hearing loss
    • Bloods – monitor serum amikacin levels and creatinine / urea

Potential Indications
BETA

Associated Adverse Effects
BETA

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