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Drug Guide
 
 

Amantadine

 
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  •  
    Oral
    Amantadine
    Symmetrel 

  • Mechanism of Action

  • Inhibits the ion channel function of M2 proteins on the viral membrane, preventing uncoating and disassembly of the virus once it enters cells.

  • Microbiology

  • Active against influenza A; no activity against influenza B.

Clinical Use

  • Indications

  • Influenza A prophylaxis.
  • Adverse Effects
  • Neuropsychiatric - dizziness, lethargy, ataxia, agitation, insomnia
  • Palpitations
  • Orthostatic hypotension
  • Dry mouth
  • Nausea / vomiting
  • Constipation
  • Livedo reticularis
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