Drug Guide
 

Alteplase

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    IV / Intraarterial
    Alteplase
    Actilyse 
    • Mechanism of Action
    • Binds to fibrin on the clot surface and activate plasminogen, resulting in its activation to plasmin and thus fibrinolysis.

Clinical Use

    • Indications
    • ST elevation myocardial infarction, within 12 hours of onset of chest pain
    • Acute ischaemic stroke, within 4.5 hours of onset of symptoms
    • Pulmonary embolism with haemodynamic compromise
    • Contraindications
    • Active bleeding
    • Recent GI / urinary bleeding
    • Recent major trauma / surgery
    • Recent ischaemic stroke
    • Intracranial haemorrhage, aneurysm, AVM or neoplasm
    • Current anticoagulant use
    • Pregnancy
    • Adverse Effects
    • Life-threatening haemorrhage
    • Hypersensitivity – rash, oedema, anaphylaxis
    • Cardiac arrhythmia
    • Hypotension
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