Alteplase
- IV / IntraarterialAlteplaseActilyse
Mechanism of Action
- Binds to fibrin on the clot surface and activate plasminogen, resulting in its activation to plasmin and thus fibrinolysis.
Clinical Use
- Indications
- ST elevation myocardial infarction, within 12 hours of onset of chest pain
- Acute ischaemic stroke, within 4.5 hours of onset of symptoms
- Pulmonary embolism with haemodynamic compromise
- Contraindications
- Active bleeding
- Recent GI / urinary bleeding
- Recent major trauma / surgery
- Recent ischaemic stroke
- Intracranial haemorrhage, aneurysm, AVM or neoplasm
- Current anticoagulant use
- Pregnancy
- Adverse Effects
- Life-threatening haemorrhage
- Hypersensitivity - rash, oedema, anaphylaxis
- Cardiac arrhythmia
- Hypotension