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Drug Guide


    IV / Intraarterial
  • Mechanism of Action

  • Binds to fibrin on the clot surface and activate plasminogen, resulting in its activation to plasmin and thus fibrinolysis.

Clinical Use

  • Indications
  • ST elevation myocardial infarction, within 12 hours of onset of chest pain
  • Acute ischaemic stroke, within 4.5 hours of onset of symptoms
  • Pulmonary embolism with haemodynamic compromise
  • Contraindications
  • Active bleeding
  • Recent GI / urinary bleeding
  • Recent major trauma / surgery
  • Recent ischaemic stroke
  • Intracranial haemorrhage, aneurysm, AVM or neoplasm
  • Current anticoagulant use
  • Pregnancy
  • Adverse Effects
  • Life-threatening haemorrhage
  • Hypersensitivity - rash, oedema, anaphylaxis
  • Cardiac arrhythmia
  • Hypotension
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