Drug Guide


    IV / Intraarterial
    • Mechanism of Action
    • Binds to fibrin on the clot surface and activate plasminogen, resulting in its activation to plasmin and thus fibrinolysis.

Clinical Use

    • Indications
    • ST elevation myocardial infarction, within 12 hours of onset of chest pain
    • Acute ischaemic stroke, within 4.5 hours of onset of symptoms
    • Pulmonary embolism with haemodynamic compromise
    • Contraindications
    • Active bleeding
    • Recent GI / urinary bleeding
    • Recent major trauma / surgery
    • Recent ischaemic stroke
    • Intracranial haemorrhage, aneurysm, AVM or neoplasm
    • Current anticoagulant use
    • Pregnancy
    • Adverse Effects
    • Life-threatening haemorrhage
    • Hypersensitivity – rash, oedema, anaphylaxis
    • Cardiac arrhythmia
    • Hypotension
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge