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Drug Guide
 
 

Alemtuzumab

 
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    IV
    Alemtuzumab
    MabCampath (CLL), LemTrada (MS) 
  • Mechanism of Action

  • A humanized monoclonal antibody that binds to CD-52 receptors found on mature lymphocytes, initiating complement-mediated and antibody-dependent cell-mediated cytotoxicity.

Clinical Use

  • Indications
  • B cell chronic lymphocytic leukaemia (CLL)
  • Relapsing multiple sclerosis (MS)
  • Adverse Effects
  • Bone marrow suppression – leucopaenia, anaemia, thrombocytopaenia
  • Nausea / vomiting / diarrhoea / anorexia
  • Headache
  • Confusion
  • Hypotension
  • Dyspnoea
  • Arthralgia / myalgia
  • Rash
  • Fatigue
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