Login or Register to unlock everything MedSchool has to offer!
Full Drug List
 

#

A

B

C

D

E

F

G

H

I

K

N

O

P

Q

R

S

T

U

V

W

Z

 
 

Alectinib

  •  
    Oral
    Alectinib
    Alecensa 
     
    Better CNS penetration than crizotinib
    • Mechanism of Action
    • Anaplastic lymphoma kinase (ALK) is a novel receptor tyrosine kinase associated with ~60% of anaplastic large-cell lymphoma and ~5% of non-small cell lung cancer. Inhibition of these receptors interrupts downstream signalling pathways and suppresses cellular proliferation.

Clinical Use

    • Indication
    • ALK-positive locally advanced or metastatic non small cell lung cancer (NSCLC).
    • Adverse Effects
    • Visual phenomena
    • Nausea / vomiting / diarrhoea
    • Neutropaenia
    • Pneumonitis
    • LFT derangement
    • Bradycardia
    • Oedema

Potential Indications
BETA

Lung Cancer
Feedback