Drug Guide
 

Adexanet Alfa

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    IV
    Adexanet Alfa
    AdexXa 
    • Mechanism of Action
    • Inactivated recombinant factor Xa that strongly binds the factor Xa inhibitors apixaban and rivaroxaban, inactivating them and preventing their anticoagulant effect.
    • Pharmacology
    • Recurrence of anticoagulation may occur following the end of the infusion.

Clinical Use

    • Indication
    • Reversal of apixaban or rivaroxaban in the event of life-threatening or uncontrolled bleeding.
    • Adverse Effects
    • Thrombotic events - due to reversal of anticoagulant
    • Infections - urinary tract infections, pneumonia
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