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Drug Guide

Adexanet Alfa

    Adexanet Alfa
  • Mechanism of Action

  • Inactivated recombinant factor Xa that strongly binds the factor Xa inhibitors apixaban and rivaroxaban, inactivating them and preventing their anticoagulant effect.
  • Pharmacology

  • Recurrence of anticoagulation may occur following the end of the infusion.

Clinical Use

  • Indications

  • Reversal of apixaban or rivaroxaban in the event of life-threatening or uncontrolled bleeding.
  • Adverse Effects
  • Thrombotic events - due to reversal of anticoagulant
  • Infections - urinary tract infections, pneumonia
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