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Actinomycin D / Dactinomycin

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    IV
    Actinomycin D / Dactinomycin

    • Mechanism of Action
    • Binds to DNA, resulting in prevention of RNA transcription and protein synthesis.
    • Pharmacology
    • Bone marrow-sparing, therefore often used when other antineoplastics are contraindicated.

Clinical Use

    • Indication
    • Certain solid organ and haematologic organ malignancies, as guided by cancer specialists and local guidelines.
    • Adverse Effects
    • Nausea / vomiting / diarrhoea / anorexia
    • Pneumonitis
    • Alopecia
    • Soft tissue damage (if extravasation)
    • Monitoring
    • Lung function.
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