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Drug Guide
 
 

Aciclovir

 
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  •  
    Oral / IV
    Aciclovir
    Herpex, zovirex 
     
    20% bioavailability; mainly used for HSV and VZV

  • Mechanism of Action

  • A nucleoside analogue that is incorporated into viral DNA by viral DNA polymerase, resulting in premature DNA termination.

  • Microbiology

  • Effective against Herpes simplex virus (HSV), varicella zoster virus (VZV) and cytomegalovirus (CMV), though impossible to reach therapeutic levels sufficient to be effective against CMV.

Clinical Use

  • Indications
  • Genital herpes
  • Cold sores
  • Herpes simplex encephalitis
  • Chickenpox (in adults)
  • Shingles
  • Ophthalmic herpes zoster

  • Adverse Effects

  • Nausea / vomiting, headache.
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