Aciclovir

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    Oral / IV
    Aciclovir
    Herpex, zovirex 
     
    20% bioavailability; mainly used for HSV and VZV
    • Mechanism of Action
    • A nucleoside analogue that is incorporated into viral DNA by viral DNA polymerase, resulting in premature DNA termination.
    • Microbiology
    • Effective against Herpes simplex virus (HSV), varicella zoster virus (VZV) and cytomegalovirus (CMV), though impossible to reach therapeutic levels sufficient to be effective against CMV.

Clinical Use

    • Indications
    • Genital herpes
    • Cold sores
    • Herpes simplex encephalitis
    • Chickenpox (in adults)
    • Shingles
    • Ophthalmic herpes zoster
    • Adverse Effects
    • Nausea / vomiting, headache.
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