Drug Guide
 

Abciximab

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    IV
    Abciximab
    Reopro 
     
    Long half-life (8-12 hours) and effect (haemostasis 72 hours)
    • Mechanism of Action
    • Inhibits glycoprotein IIb/IIIa receptors, preventing them from binding to plasma adhesive proteins such as fibrinogen and von Willebrand factor (vWF) and facilitating platelet adhesion.

Clinical Use

    • Indication
    • Prevention of cardiac ischaemia post percutaneous coronary intervention (with aspirin + heparin)
    • Contraindications
    • Active or recent internal bleeding
    • Past ischaemic stroke with residual deficit
    • Recent major trauma or surgery
    • Intracranial neoplasm, AVM or aneurysm
    • Past vasculitis
    • Adverse Effects
    • Bleeding
    • Thrombocytopaenia
    • Nausea / vomiting
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