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Drug Guide


    Long half-life (8-12 hours) and effect (haemostasis 72 hours)
  • Mechanism of Action

  • Inhibits glycoprotein IIb/IIIa receptors, preventing them from binding to plasma adhesive proteins such as fibrinogen and von Willebrand factor (vWF) and facilitating platelet adhesion.

Clinical Use

  • Indications

  • Prevention of cardiac ischaemia post percutaneous coronary intervention (with aspirin + heparin)
  • Contraindications
  • Active or recent internal bleeding
  • Past ischaemic stroke with residual deficit
  • Recent major trauma or surgery
  • Intracranial neoplasm, AVM or aneurysm
  • Past vasculitis
  • Adverse Effects
  • Bleeding
  • Thrombocytopaenia
  • Nausea / vomiting
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