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Drug Guide
 
 

Abatacept

 
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    IV / Subcut
    Abatacept
    Orencia 
    • Mechanism of Action
    • A fusion protein with the Fc fragment of human IgG1 linked to the extracellular domain of CTLA-4. Binds to CD80 / CD86 on antigen presenting cells and prevents binding by CD28 on T lymphocytes, resulting in lack of a costimulatory response and reduced T cell activation.

Clinical Use

    • Indications
    • Contraindications
    • Not to be used concurrently with other biologic DMARDs.
    • Adverse Effects
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