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Drug Guide


    IV / Subcut
  • Mechanism of Action

  • A fusion protein with the Fc fragment of human IgG1 linked to the extracellular domain of CTLA-4. Binds to CD80 / CD86 on antigen presenting cells and prevents binding by CD28 on T lymphocytes, resulting in lack of a costimulatory response and reduced T cell activation.

Clinical Use

  • Indications
  • Moderate to severe rheumatoid arthritis
  • Severe juvenile idiopathic arthritis
  • Psoriatic arthritis refractory to other DMARDs
  • Contraindications

  • Not to be used concurrently with other biologic DMARDs.
  • Adverse Effects
  • Injection site reactions
  • Infections (particuarly upper respiratory tract infection)
  • Headache
  • Dizziness
  • Nausea / vomiting / diarrhoea
  • Abdominal pain
  • Mouth ulcers
  • Hypertension
  • LFT derangement
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