×
MedSchool: Ace Your OSCEsThe Medical Company
 
 
 
 
 
GET - On the App Store
View
Drug Guide
 
 

6-Mercaptopurine

 
Bookmark
  •  
    Oral
    6-Mercaptopurine
    Purinethol 
  • Mechanism of Action

  • A prodrug that is converted to a purine analogue which inhibits purine synthesis, disrupting DNA synthesis and reducing T cell activation.

Clinical Use

  • Indications
  • Inflammatory bowel disease non-responsive to other medications
  • Acute leukaemia
  • Adverse Effects
  • Bone marrow suppression - anaemia / leukopaenia / thrombocytopaenia
  • Gastrointestinal - nausea / vomiting / diarrhea
  • Hepatotoxicity - elevated LFTs
  • Skin - rash
  • Monitoring

  • Monthly full blood count, renal function and LFTs.
Want more info like this?
  • Your electronic clinical medicine handbook
  • Guides to help pass your exams
  • Tools every medical student needs
  • Quick diagrams to have the answers, fast
  • Quizzes to test your knowledge
Sign Up Now
   
 
 

Snapshot: Initialising...