Drug Guide
 

6-Mercaptopurine

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    Oral
    6-Mercaptopurine
    Purinethol 
    • Mechanism of Action
    • A prodrug that is converted to a purine analogue which inhibits purine synthesis, disrupting DNA synthesis and reducing T cell activation.

Clinical Use

    • Indications
    • Inflammatory bowel disease non-responsive to other medications
    • Acute leukaemia
    • Adverse Effects
    • Bone marrow suppression - anaemia / leukopaenia / thrombocytopaenia
    • Gastrointestinal - nausea / vomiting / diarrhea
    • Hepatotoxicity - elevated LFTs
    • Skin - rash
    • Monitoring
    • Monthly full blood count, renal function and LFTs.
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