Drug Guide

5-Fluorouracil (5-FU)

    5-Fluorouracil (5-FU)

    • Mechanism of Action
    • Inhibits thymidylate synthase, resulting in reduced production of dTMP and reduced DNA synthesis.

Clinical Use

    • Indication
    • Certain solid organ malignancies, as guided by cancer specialists and local guidelines.
    • Adverse Effects
    • Severe diarrhoea
    • Nausea / vomiting
    • Alopecia
    • Leucopaenia
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