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5-Fluorouracil (5-FU)

 
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    IV
    5-Fluorouracil (5-FU)

  • Mechanism of Action

  • Inhibits thymidylate synthase, resulting in reduced production of dTMP and reduced DNA synthesis.

Clinical Use

  • Indications

  • Certain solid organ malignancies, as guided by cancer specialists and local guidelines.
  • Adverse Effects
  • Severe diarrhoea
  • Nausea / vomiting
  • Alopecia
  • Leucopaenia
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